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Human Cytomegalovirus UL4 is Required for Viral Reactivation via Cellular Reprogramming in Latently Infected CD34+ Progenitor Cells and Humanized Mice

2026-06-29

Abstract excerpt

Human cytomegalovirus (HCMV) remains a significant cause of morbidity and mortality after both solid organ and hematopoietic stem cell transplant, due to bone marrow stem cell engraftment failure, myelosuppression, and immunosuppression. While direct infection and viral replication lead to disease, latent infection in the CD34+ hematopoietic progenitor cell (HPC) pool has direct and indirect effects on hematopoies...

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Literature Corpus work: f7697739-1a4d-57ba-955f-3e0aa772b119
DOI: 10.64898/2026.06.28.735103

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