Article

Biophysical Kv channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s

2021-10-26

Abstract excerpt

<h4>Summary</h4> In Alzheimer’s disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversial. Toxic plaques and tangles correlate with progressive neuropathology, yet disruptions in circuit activity emerge before their deposition in AD models and patients. Parvalbumin (PV) interneurons are...

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Literature Corpus work: dfe7d283-5a5d-5857-bda4-77d977853467
DOI: 10.1101/2021.10.25.465789

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