Article

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease Pathogenesis

2023-08-29

Abstract excerpt

<h4>ABSTRACT</h4> The full impact of apolipoprotein E4 (APOE4), the strongest genetic risk factor for Alzheimer’s disease (AD), on neuronal and network function remains unclear. We found hippocampal region-specific network hyperexcitability in young APOE4 knock-in (E4-KI) mice which predicted cognitive deficits at old age. Network hyperexcitability in young E4-KI mice was mediated by hippocampal region-specific s...

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Literature Corpus work: b695cdcd-8062-55ec-be3d-bf0bcbf4ba6e
DOI: 10.1101/2023.08.28.555153

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