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Article

Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Apr 2015

Hall Alicia M, Throesch Benjamin T, Buckingham Susan C, Markwardt Sean J, Peng Yin, Wang Qin, Hoffman Dax A, Roberson Erik D

Abstract excerpt

Neuronal hyperexcitability occurs early in the pathogenesis of Alzheimer's disease (AD) and contributes to network dysfunction in AD patients. In other disorders with neuronal hyperexcitability, dysfunction in the dendrites often contributes, but dendritic excitability has not been directly examined in AD models. We used dendritic patch-clamp recordings to measure dendritic excitability in the CA1 region of the...

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Identifiers

PMID: 25878292
DOI: 10.1523/JNEUROSCI.2552-14.2015
PMCID: PMC4397611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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