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Article

NPTX2 and cognitive dysfunction in Alzheimer’s Disease

23 Mar 2017

Abstract excerpt

Memory loss in Alzheimer’s disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of the hippocampus and cortex with fast-spiking parvalbumin (PV) interneurons that control network excitability and rhythmicity. Excitatory synapses on PV interneurons are dependent on the AMPA receptor subunit...

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PMID: 28440221
DOI: 10.7554/elife.23798

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