Article

Alzheimer’s disease induced neurons bearing <i>PSEN1</i> mutations exhibit reduced excitability

2024-03-23

Abstract excerpt

Alzheimer’s disease (AD) is a devastating neurodegenerative condition that affects memory and cognition, characterized by neuronal loss and currently lacking a cure. Mutations in PSEN1 (Presenilin 1) are among the most common causes of early-onset familial AD (fAD). While changes in neuronal excitability are believed to be early indicators of AD progression, the link between PSEN1 mutations and neuronal excitabi...

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Literature Corpus work: 1360efed-77c1-5693-92c4-d8eaec41a4e4
DOI: 10.1101/2024.03.22.586207

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