Article

K <sub>ATP</sub> channel mutation disrupts hippocampal network activity and nocturnal γ shifts

2023-06-21

Abstract excerpt

ATP-sensitive potassium (K ATP ) channels enable ATP to control the membrane potential and insulin secretion. Humans affected by severe activating mutations in K ATP channels suffer from developmental d elay, e pilepsy and n eonatal d iabetes (DEND syndrome). While the diabetes in DEND syndrome is well understood, the pathophysiology of the neurological symptoms remains unclear. We hypothesized that parvalbu...

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Literature Corpus work: 0d00e932-387e-5b8c-a69c-a574273fd1b6
DOI: 10.1101/2023.06.18.545438

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