Article

<i>CHRNA5</i> links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s Disease

2022-05-05

Abstract excerpt

Changes in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in Alzheimer’s Disease (AD). Protective and cognitive-enhancing roles for the nicotinic α5 subunit have been identified, but this gene has not been closely examined in the context of human aging and dementia. Therefore, we investigate the nicotinic α5 gene CHRNA5 and the impact of relevant single nucleotide poly...

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Literature Corpus work: 9e5dc03d-4fed-5116-a160-8c145a215296
DOI: 10.1101/2022.05.03.490491

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