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Early amyloid spine response and impaired synaptic transmission of pyramidal neurons in human biopsies with Alzheimer’s Disease-related pathology

2025-01-07

Abstract excerpt

Studies of neuronal functions during the pathological progression of Alzheimer’s disease (AD) in humans are limited due to the lack of live human brain tissue from patients with AD. To address this gap, we have established an exceptional approach to study the electrophysiological properties and cell morphologies of human neurons in acute slices obtained from cortical biopsies of patients with idiopathic normal pre...

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Literature Corpus work
1a035073-d1b2-5fd5-9954-4aa93dd729c6
DOI
10.1101/2025.01.07.630516
Open publication

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Early amyloid spine response and impaired synaptic transmission of pyramidal neurons in human biopsies with Alzheimer’s Disease-related pathologyDOI 10.1101/2025.01.07.630516
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