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Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?

Translational psychiatry - 22 Jun 2022

Targa Dias Anastacio Helena, Matosin Natalie, Ooi Lezanne

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of cognitive abilities and ultimately, death. With no cure available, limited treatments mostly focus on symptom management. Identifying early changes in the disease course may provide new therapeutic targets to halt or reverse disease progression. Clinical studies have shown that cortical and hippocampal hyperactivity are a...

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PMID: 35732622
DOI: 10.1038/s41398-022-02024-7
PMCID: PMC9217953

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