Article

Genetically Adjusted PSA Levels for Prostate Cancer Screening

2022-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for genetic determinants of constitutive, non-cancer-related PSA variation has potential to improve screening utility. We discovered 128 genome-wide significant associations ( P <5×10 -8 ) in a multi-ancestry meta-a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dfc14aa5-10ac-51d1-9ad5-3f7b2c2413b8
DOI: 10.1101/2022.04.18.22273850

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetically Adjusted PSA Levels for Prostate Cancer ScreeningDOI 10.1101/2022.04.18.22273850Read

Germline polygenic score for prostate cancer aggressivenessSemantic proximity Read

Genetic Risk Assessment of Lethal Prostate Cancer Using Polygenic Risk Score and Hereditary Cancer Susceptibility genesSemantic proximity Read

Assessment of a Polygenic Risk Score in Screening for Prostate CancerSemantic proximity Read

Genetic risk assessment of lethal prostate cancer using polygenic risk score and hereditary cancer susceptibility genes.Semantic proximity Read

Precision Prostate Cancer Screening with a Polygenic Risk ScoreSemantic proximity Read

Validation of a prostate cancer polygenic risk score.Semantic proximity Read

Polygenic risk score for genetic evaluation of prostate cancer risk in Asian populations: A narrative review.Semantic proximity Read

Polygenic Risk Scores in Prostate Cancer Risk Assessment and Screening.Semantic proximity Read

Clinical consequences of a genetic predisposition toward higher benign prostate-specific antigen levels.Semantic proximity Read

Clinical features of prostate cancer by polygenic risk score.Semantic proximity Read

Polygenic risk score improves prostate cancer risk prediction: results from the Stockholm-1 cohort study.Semantic proximity Read

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.Semantic proximity Read