Genetic Risk Assessment of Lethal Prostate Cancer Using Polygenic Risk Score and Hereditary Cancer Susceptibility genes

Abstract excerpt

<title>Abstract</title> <p>Background The genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due to the lack of aggressiveness-related single-nucleotide polymorphisms (SNPs). Prostate volume (PV) is a potential well-established risk factor for aggressive PCa, we hypothesize that polygenic risk score (PRS) based on benign prostate hyperplasia (BPH) or PV-related SNPs may also predict the risk...

Topics

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• Early Detection of Cancer
• Genetic Predisposition to Disease
• Mutation
• Prostate
• Prostatic Hyperplasia
• Prostatic Neoplasms
• Risk Assessment
• Risk Factors

Identifiers and source

Literature Corpus work

bc0db2f1-799c-599f-9a78-22c7087d72d0

DOI

10.21203/rs.3.rs-2446801/v1