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Article

Genetic risk assessment of lethal prostate cancer using polygenic risk score and hereditary cancer susceptibility genes.

Journal of translational medicine - 6 Jul 2023

Ruan Xiaohao, Huang Da, Huang Jingyi, Tsu James Hok-Leung, Na Rong

Abstract excerpt

BACKGROUND: The genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due to the lack of aggressiveness-related single-nucleotide polymorphisms (SNPs). Prostate volume (PV) is a potential well-established risk factor for aggressive PCa, we hypothesize that polygenic risk score (PRS) based on benign prostate hyperplasia (BPH) or PV-related SNPs may also predict the risk of aggressive PCa or PCa...

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Genetic Predisposition to Disease
Prostatic Hyperplasia
Prostatic Neoplasms
Risk Assessment
Risk Factors

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PMID: 37415201
DOI: 10.1186/s12967-023-04316-y
PMCID: PMC10327136

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