Article
Polygenic risk score improves prostate cancer risk prediction: results from the Stockholm-1 cohort study.
European urology - 1 Jul 2011
Aly Markus, Wiklund Fredrik, Xu Jianfeng, Isaacs William B, Eklund Martin, D'Amato Mauro, Adolfsson Jan, Grönberg Henrik
Abstract excerpt
BACKGROUND: More than 1 million prostate biopsies are conducted yearly in the United States. The low specificity of prostate-specific antigen (PSA) results in diagnostic biopsies in men without prostate cancer (PCa). Additional information, such as genetic markers, could be used to avoid unnecessary biopsies. OBJECTIVE: To determine whether single nucleotide polymorphisms (SNPs) associated with PCa can be used to...
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