Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical consequences of a genetic predisposition toward higher benign prostate-specific antigen levels.

EBioMedicine - 1 Nov 2023

Shi Mingjian, Shelley John P, Schaffer Kerry R, Tosoian Jeffrey J, Bagheri Minoo, Witte John S, Kachuri Linda, Mosley Jonathan D

Abstract excerpt

BACKGROUND: Prostate-specific antigen (PSA) levels are influenced by genetic variation unrelated to prostate cancer risk. Whether a genetic predisposition to a higher PSA level predisposes to a diagnostic work-up for prostate cancer is not known. METHODS: Participants were 3110 men of African and European ancestries ages 45-70, without prostate cancer and with a baseline PSA < 4 ng/mL, undergoing routine clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proportional Hazards Models

Share to Prostate-Specific Antigen

Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 37865044
DOI: 10.1016/j.ebiom.2023.104838
PMCID: PMC10597757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical consequences of a genetic predisposition toward higher benign prostate-specific antigen levels.PMID 37865044Read ↗

Assessment of a Polygenic Risk Score in Screening for Prostate CancerSemantic proximity Read ↗

Genetically Adjusted PSA Levels for Prostate Cancer ScreeningSemantic proximity Read ↗

Genetics of prostate cancer: a review of latest evidence.Semantic proximity Read ↗

Men with a susceptibility to prostate cancer and the role of genetic based screeningSemantic proximity Read ↗

A genetic risk score to guide age-specific, personalized prostate cancer screeningSemantic proximity Read ↗

Translating genetic risk factors for prostate cancer to the clinic: 2013 and beyond.Semantic proximity Read ↗

Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK BiobankSemantic proximity Read ↗

Germline Genetics of Prostate Cancer: Time to Incorporate Genetics into Early Detection ToolsSemantic proximity Read ↗

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.Semantic proximity Read ↗

Prostate cancer risk alleles significantly improve disease detection and are associated with aggressive features in patients with a "normal" prostate specific antigen and digital rectal examination.Semantic proximity Read ↗

Genetic Risk Prediction for Prostate Cancer: Implications for Early Detection and Prevention.Semantic proximity Read ↗

A genetic score can identify men at high risk for prostate cancer among men with prostate-specific antigen of 1-3 ng/ml.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.