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Article

Polygenic Risk Scores in Prostate Cancer Risk Assessment and Screening.

The Urologic clinics of North America - 1 Aug 2021

Byrne Lindsey, Toland Amanda Ewart

Abstract excerpt

More than 40% of the risk of developing prostate cancer (PCa) is from genetic factors. Genome-wide association studies have led to the discovery of more than 140 variants associated with PCa risk. Polygenic risk scores (PRS) generated using these variants show promise in identifying individuals at much higher (and lower) lifetime risk than the average man. PCa PRS also improve the predictive value of...

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Identifiers

PMID: 34210493
DOI: 10.1016/j.ucl.2021.03.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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