Article
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.
Nature genetics - 1 Feb 2025
Hoffmann Thomas J, Graff Rebecca E, Madduri Ravi K, Rodriguez Alex A, Cario Clinton L, Feng Karen, Jiang Yu, Wang Anqi, Klein Robert J, Pierce Brandon L, Eggener Scott, Tong Lin, Blot William, Long Jirong, Goss Louisa B, Darst Burcu F, Rebbeck Timothy, Lachance Joseph, Andrews Caroline, Adebiyi Akindele O, Adusei Ben, Aisuodionoe-Shadrach Oseremen I, Fernandez Pedro W, Jalloh Mohamed, Janivara Rohini, Chen Wenlong C, Mensah James E, Agalliu Ilir, Berndt Sonja I, Shelley John P, Schaffer Kerry, Machiela Mitchell J, Freedman Neal D, Huang Wen-Yi, Li Shengchao A, Goodman Phyllis J, Till Cathee, Thompson Ian, Lilja Hans, Ranatunga Dilrini K, Presti Joseph, Van Den Eeden Stephen K, Chanock Stephen J, Mosley Jonathan D, Conti David V, Haiman Christopher A, Justice Amy C, Kachuri Linda, Witte John S
Abstract excerpt
We conducted a multiancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry, 58,236 African ancestry, 23,546 Hispanic/Latino and 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (P ≤ 5 × 10-8) variants, 184 of which were novel. Most demonstrated evidence of...
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