Clinical features of prostate cancer by polygenic risk score.

doi:10.1007/s10689-024-00369-0

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Clinical features of prostate cancer by polygenic risk score.

Familial cancer - 1 Nov 2024

Spears Christina, Xu Menglin, Shoben Abigail, Dason Shawn, Toland Amanda Ewart, Byrne Lindsey

Abstract excerpt

Genome-wide association studies have identified more than 290 single nucleotide variants (SNVs) associated with prostate cancer. These SNVs can be combined to generate a Polygenic Risk Score (PRS), which estimates an individual's risk to develop prostate cancer. Identifying individuals at higher risk for prostate cancer using PRS could allow for personalized screening recommendations, improve current screening...

Topics

Humans
Male
Prostatic Neoplasms
Middle Aged
Aged
Genome-Wide Association Study
Multifactorial Inheritance
Genetic Predisposition to Disease
Retrospective Studies
Polymorphism, Single Nucleotide
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged, 80 and over

Risk Assessment

Risk Factors

Neoplasm Grading

Genetic Testing

Genetic Risk Score

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Identifiers

PMID: 38619781
DOI: 10.1007/s10689-024-00369-0
PMCID: PMC11512885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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