Article
Validation of a prostate cancer polygenic risk score.
The Prostate - 1 Nov 2020
Black Mary H, Li Shuwei, LaDuca Holly, Lo Min-Tzu, Chen Jefferey, Hoiness Robert, Gutierrez Stephanie, Tippin-Davis Brigette, Lu Hsiao-Mei, Gielzak Marta, Wiley Kathleen, Shi Zhuqing, Wei Jun, Zheng Siqun Lilly, Helfand Brian T, Isaacs William, Xu Jianfeng
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified over 100 single-nucleotide polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores (PRS) based on their combined genotypes have been developed for risk stratification. We aimed to assess the contribution of PRS to PrCa risk in a large multisite study. METHODS: The sample included 1972 PrCa cases and 1919 unaffected...
Topics
- Adult
- Aged
- Case-Control Studies
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- High-Throughput Nucleotide Sequencing
- Humans
- Male
- Middle Aged