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Assessment of a Polygenic Risk Score in Screening for Prostate Cancer

9 Apr 2025

Abstract excerpt

BACKGROUND: The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified common germline variants in persons with prostate cancer, which can be used to calculate a polygenic risk score associated with risk of prostate cancer. METHODS: We recruited persons 55 to 69 years of age...

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PMID: 40214032
DOI: 10.1056/nejmoa2407934

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