Article

Beyond Lipidation: CSF APOE4 Protein Burden, Not HDL Subclass, Drives Tau Associations in APOE4 Alzheimer’s Disease

2026-04-24

Abstract excerpt

<title>Abstract</title> Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet whether its pathogenic effects are driven by HDL lipidation state or by elevated APOE4 levels in the CNS remains unclear. Using ADNI data, we analyzed cerebrospinal fluid (CSF) and plasma small and large HDL particle concentrations, total APOE levels, and isoform-specific APOE3...

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Literature Corpus work: df5e7383-4930-5066-ac1d-cbf96e1701e5
DOI: 10.21203/rs.3.rs-9349576/v1

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