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APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics

17 Feb 2021

Abstract excerpt

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations. One risk factor for developing AD is the APOE gene coding for the apolipoprotein E protein (apoE). Humans have three versions of APOE gene: ε2, ε3, and ε4 allele. Carrying the ε4 allele is an AD risk factor while carrying the ε2 allele is protective. ApoE...

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PMID: 33679311
DOI: 10.3389/fnins.2021.630502

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