Don't forget about tau: the effects of ApoE4 genotype on Alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia Competence Network.

doi:10.1007/s00702-022-02461-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Don't forget about tau: the effects of ApoE4 genotype on Alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia Competence Network.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jun 2022

Benson Gloria S, Bauer Chris, Hausner Lucrezia, Couturier Samuel, Lewczuk Piotr, Peters Oliver, Hüll Michael, Jahn Holger, Jessen Frank, Pantel Johannes, Teipel Stefan J, Wagner Michael, Schuchhardt Johannes, Wiltfang Jens, Kornhuber Johannes, Frölich Lutz

Abstract excerpt

ApoE4, the strongest genetic risk factor for Alzheimer's disease (AD), has been shown to be associated with both beta-amyloid (Aβ) and tau pathology, with the strongest evidence for effects on Aβ, while the association between ApoE4 and tau pathology remains inconsistent. This study aimed to investigate the associations between ApoE4 with CSF Aβ42, total tau (t-tau), phospho-tau181 (p-tau), and with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Apolipoprotein E4

Share to Biomarkers

Share to Cognitive Dysfunction

Share to Genotype

Share to Peptide Fragments

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 35061102
DOI: 10.1007/s00702-022-02461-0
PMCID: PMC9188507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Don't forget about tau: the effects of ApoE4 genotype on Alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia Competence Network.PMID 35061102Read ↗

Differential Associations of APOEɛ2 and APOEɛ4 Genotypes with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Individuals Without Dementia.Semantic proximity Read ↗

<i>APOE4</i>impact on soluble and insoluble tau pathology is mostly influenced by amyloid-betaSemantic proximity Read ↗

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.Semantic proximity Read ↗

Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum.Semantic proximity Read ↗

An Integrated Bioinformatics Approach for Identifying Genetic Markers that Predict Cerebrospinal Fluid Biomarker p-tau181/Aβ1-42 Ratio in ApoE4-Negative Mild Cognitive Impairment Patients.Semantic proximity Read ↗

Progression from MCI to AD: predictive value of CSF Aβ42 is modified by APOE genotype.Semantic proximity Read ↗

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.Semantic proximity Read ↗

APOE ε4 carriership status enhances age-related changes in Alzheimer’s disease plasma biomarkers concentrationsSemantic proximity Read ↗

Effects of APOE ε4 and amyloid pathology on longitudinal tau biomarkers, neurodegeneration, and cognitive decline in mild cognitive impairment.Semantic proximity Read ↗

Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrationsSemantic proximity Read ↗

Beyond Lipidation: CSF APOE4 Protein Burden, Not HDL Subclass, Drives Tau Associations in APOE4 Alzheimer’s DiseaseSemantic proximity Read ↗

Association of APOE ε4/ε4 with fluid biomarkers in patients from the PUMCH dementia cohortSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.