Article

Novel Plasma Proteins Associated With Alzheimer’s Disease Risk in APOE ε4 Carriers and Non-carriers

2026-08-03

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<title>Abstract</title> <p>Background Whether plasma protein associations with Alzheimer’s disease (AD) differ by genetic risk remains unclear. Methods We studied 18,212 UK Biobank participants aged ≥ 60 years with Olink Explore 3072 proteomic data, APOE genotypes, and AD polygenic risk scores. Protein-by-genetic risk interactions were screened, followed by genetic risk-stratified association and mediation anal...

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Literature Corpus work: 8b48ad73-a9cd-5ec2-ad21-6d076bfa87e8
DOI: 10.21203/rs.3.rs-10359931/v1

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