Article

<i>APOE4</i>impact on soluble and insoluble tau pathology is mostly influenced by amyloid-beta

2024-09-23

Abstract excerpt

The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). While APOE4 is strongly associated with amyloid-beta (Aβ) accumulation, its relationship with tau accumulation is less understood. Studies evaluating the role of APOE4 on tau accumulation have shown conflicting results, particularly regarding the independence of these associations from Aβ load. To clarify the relations bet...

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Literature Corpus work: 6d298e98-32fb-5f0d-b6ee-63666365cde2
DOI: 10.1101/2024.09.20.24314064

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