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Article

APOE4 genotypes and the trajectory of biomarkers, neuroimaging, and cognitive measures in Alzheimer's Disease: A mixed-effects disease progression model.

Journal of pharmacokinetics and pharmacodynamics - 30 Aug 2025

Essenburg Carson, Ramanathan Murali

Abstract excerpt

BACKGROUND: The ε4 allele of the apolipoprotein E gene (APOE4) is a major risk factor for developing sporadic Alzheimer's disease (AD). APOE4 homozygosity has been recently proposed as the defining signature of a genetic form of AD. The goal was to assess the role, if any, of APOE4 in AD progression using a mixed-effects disease progression model-informed approach. METHODS: Data from the Alzheimer's Disease...

Read the complete abstract on PubMed

Topics

Humans
Alzheimer Disease
Apolipoprotein E4
Disease Progression
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biomarkers

Aged

Neuroimaging

Genotype

Cognitive Dysfunction

Magnetic Resonance Imaging

Cognition

Amyloid beta-Peptides

Neuropsychological Tests

tau Proteins

Aged, 80 and over

Source

Identifiers

PMID: 40884585
DOI: 10.1007/s10928-025-09996-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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