Article

Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing

2022-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Genome editing tools, especially CRISPR/Cas9-based strategies, have transformed biomedical research and opened opportunities for developing curative treatments for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of undesired mutations represent major limitations for genome editing applications. Both issues arise from the interplay between the m...

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Literature Corpus work: df4b7880-0877-5175-a301-eb2d588365aa
DOI: 10.1101/2022.12.15.520396

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