Article

Dual Activities of an X-family DNA Polymerase Regulate CRISPR-Induced Insertional Mutagenesis Across Species

2024-01-19

Abstract excerpt

<title>Abstract</title> <p>The canonical non-homologous end joining (c-NHEJ) repair pathway has generally been considered a highly efficient and stochastic repair process. Yet recent studies indicated that c-NHEJ-mediated CRISPR-Cas9 mutagenesis, primarily leading to 1-bp insertions and small deletions, may be highly predictable. This observation has spurred the development of in-silico programs with remarkable a...

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Literature Corpus work: 542dbeef-c790-5f98-94e9-b6d980e64f98
DOI: 10.21203/rs.3.rs-3851715/v1

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