Article

Decorating chromatin for enhanced genome editing using CRISPR-Cas9

2022-03-16

Abstract excerpt

CRISPR-associated (Cas) enzymes have revolutionized biology by enabling RNA-guided genome editing. Homology-directed repair (HDR) in the presence of donor templates is currently the most versatile method to introduce precise edits following CRISPR-Cas-induced double-stranded DNA cuts, but HDR efficiency is generally low relative to end-joining pathways that lead to insertions and deletions (indels). We tested the...

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Literature Corpus work: 2dd7c8f5-a90c-5050-a81a-2706e349f2b8
DOI: 10.1101/2022.03.15.484540

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