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A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells

18 Apr 2023

Abstract excerpt

Precise genome editing requires the resolution of nuclease-induced DNA double strand breaks (DSBs) via the homology-directed repair (HDR) pathway. In mammals, this is typically outcompeted by non-homologous end-joining (NHEJ) that can generate potentially genotoxic insertion/deletion mutations at DSB sites. Because of higher efficacy, clinical genome editing has been restricted to imperfect but efficient...

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PMID: 37070192
DOI: 10.1093/nar/gkad255

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