Article
Decoding non-random mutational signatures at Cas9 targeted sites.
Nucleic acids research - 19 Sept 2018
Taheri-Ghahfarokhi Amir, Taylor Benjamin J M, Nitsch Roberto, Lundin Anders, Cavallo Anna-Lina, Madeyski-Bengtson Katja, Karlsson Fredrik, Clausen Maryam, Hicks Ryan, Mayr Lorenz M, Bohlooly-Y Mohammad, Maresca Marcello
Abstract excerpt
The mutation patterns at Cas9 targeted sites contain unique information regarding the nuclease activity and repair mechanisms in mammalian cells. However, analytical framework for extracting such information are lacking. Here, we present a novel computational platform called Rational InDel Meta-Analysis (RIMA) that enables an in-depth comprehensive analysis of Cas9-induced genetic alterations, especially InDels...
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