Global detection of DNA repair outcomes induced by CRISPR-Cas9

Abstract excerpt

CRISPR-Cas9 generates double-stranded DNA breaks (DSBs) to activate cellular DNA repair pathways for genome editing. The repair of DSBs leads to small insertions or deletions (indels) and other complex byproducts, including large deletions and chromosomal translocations. Indels are well understood to disrupt target genes, while the other deleterious byproducts remain elusive. We developed a new in silico analysis...

Topics

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• Cell Line
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Genetic Vectors
• High-Throughput Nucleotide Sequencing
• Mice
• Mutation
• Species Specificity

Identifiers and source

Literature Corpus work

06149395-f726-5f86-9a58-5999f720cc96

DOI

10.1101/2021.02.15.431335