Article

Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing

2023-05-02

Abstract excerpt

<h4>ABSTRACT</h4> The efficiency and outcome of CRISPR/Cas9 editing depends on the chromatin state at the cut site. It has been shown that changing the chromatin state can influence both the efficiency and repair outcome, and epigenetic drugs have been used to improve Cas9 editing. However, because the target proteins of these drugs are not homogeneously distributed across the genome, the efficacy of these drugs...

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Literature Corpus work: ecfbd1cc-ffca-5f05-8e9d-d2b804f4f3fa
DOI: 10.1101/2023.05.02.539047

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