Article

A p53-dependent FBXO44-RAD18 axis limits mutagenesis by terminating translesion DNA synthesis

2026-07-28

Abstract excerpt

DNA lesions continually challenge genome replication and threaten genome integrity. DNA damage tolerance pathways, including translesion DNA synthesis (TLS), allow cells to bypass lesions and prevent stalled forks from collapsing into double-strand breaks. Because TLS polymerases are intrinsically error-prone, however, this pathway must be tightly restrained; persistent or deregulated TLS can increase mutagenesis,...

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Literature Corpus work: 6ebdf4f7-7d6f-543b-92a3-98d105f539b1
DOI: 10.64898/2026.07.27.739831

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