Article

Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations

2017-10-10

Abstract excerpt

Spontaneously occurring mutations are of great relevance in diverse fields including biochemistry, oncology, evolutionary biology, and human genetics. Studies in experimental systems have identified a multitude of mutational mechanisms including DNA replication infidelity as well as many forms of DNA damage followed by inefficient repair or replicative bypass. However, the relative contributions of these mechanism...

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Literature Corpus work: b9c4f4e3-5272-5adb-ad27-d7ec792ec2b6
DOI: 10.1101/200691

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