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Article

Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment.

DNA repair - 1 Sept 2023

Tan Ke, Song Yizhe, Xu Min, You Zhongsheng

Abstract excerpt

DNA replication stress (RS) is frequently induced by oncogene activation and is believed to promote tumorigenesis. However, clinical evidence for the role of oncogene-induced RS in tumorigenesis remains scarce, and the mechanisms by which RS promotes cancer development remain incompletely understood. By performing a series of bioinformatic analyses on the oncogene E2F1, other RS-inducing factors, and replication...

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Identifiers

PMID: 37453246
DOI: 10.1016/j.dnarep.2023.103531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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