Article

A universal molecular mechanism driving aging

2024-01-06

Abstract excerpt

How cell replication ultimately results in aging and the Hayflick limit are not fully understood. Here we show that clock-like accumulation of DNA G-quadruplexes (G4s) throughout cell replication drives conserved aging mechanisms. G4 stimulates transcription-replication interactions to delay genome replication and impairs DNA re-methylation and histone modification recovery, leading to loss of heterochromatin. Thi...

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Literature Corpus work: 0f4d39d2-2b34-5bc2-97cf-b2126650d8cf
DOI: 10.1101/2024.01.06.574476

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