Article

Quantifying replication stress in cancer without proliferation confounding

2025-04-15

Abstract excerpt

Replication stress (RS) is a major driver of genomic instability and cancer development, caused by impaired DNA replication that can lead to chromosomal instability (CIN). Although RS is mechanistically linked to CIN, its relationship with cellular proliferation is complex. Depending on the context, RS can either promote or suppress cell growth. Existing RS gene expression signatures overlook this complexity, rely...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f22979f-8d55-5980-8ca4-db9064d7bc27
DOI: 10.1101/2025.04.10.648133

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantifying replication stress in cancer without proliferation confoundingDOI 10.1101/2025.04.10.648133Read

Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment.Semantic proximity Read

Potential biomarkers of DNA replication stress in cancer.Semantic proximity Read

DNA replication stress and cancer: cause or cure?Semantic proximity Read

Replicative Instability Drives Cancer ProgressionSemantic proximity Read

Identification of critical factors of the replication stress response in human cellsSemantic proximity Read

DNA replication stress as a hallmark of cancer.Semantic proximity Read

Transcription-Coupled Repair as a Mutagenic Mechanism During Replication StressSemantic proximity Read

Transcription-Coupled Repair Promotes the Retention of Mutations in Coding Regions During Replication Stress.Semantic proximity Read

Increased replication origin firing links replication stress to whole chromosomal instability in human cancerSemantic proximity Read

Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.Semantic proximity Read

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.Semantic proximity Read

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cellsSemantic proximity Read