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Article

Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.

Cell reports - 15 May 2018

McGrail Daniel J, Lin Curtis Chun-Jen, Dai Hui, Mo Wei, Li Yang, Stephan Clifford, Davies Peter, Lu Zhimin, Mills Gordon B, Lee Ju-Seog, Lin Shiaw-Yih

Abstract excerpt

Extensive spontaneous DNA damage from oncogene-induced replication stress is ubiquitous in precancerous lesions. While this damage induces differentiation, senescence, or apoptosis in normal cells, defects in DNA replication stress response (RSR) allow cells to continue proliferating, ultimately leading to early tumorigenesis. Using systems-level approaches, we developed a replication stress response defect gene...

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Identifiers

PMID: 29768207
DOI: 10.1016/j.celrep.2018.04.068

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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