Article

Systematic identification of pH-sensing amyloid core motifs reveals a widespread mechanism for reversible protein assembly upon stress

2026-08-12

Abstract excerpt

Unlike irreversible pathological amyloids, reversible fibrils can be regulated via pH-sensing core motifs, characterized by amyloid properties unleashed upon stress-induced protonation of critical residues. Here, we combined bioinformatic predictions and an in vitro validation pipeline to search for pH-responsive, reversible amyloid core peptides in yeast and human proteomes. This approach uncovered biophysical p...

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Literature Corpus work: df2c0a3c-b5cf-57ff-91e8-62d1255d7de7
DOI: 10.64898/2026.08.11.744147

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