Article
Composition-based prediction and rational manipulation of prion-like domain recruitment to stress granules.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2020
Boncella Amy E, Shattuck Jenifer E, Cascarina Sean M, Paul Kacy R, Baer Matthew H, Fomicheva Anastasia, Lamb Andrew K, Ross Eric D
Abstract excerpt
Mutations in a number of stress granule-associated proteins have been linked to various neurodegenerative diseases. Several of these mutations are found in aggregation-prone prion-like domains (PrLDs) within these proteins. In this work, we examine the sequence features governing PrLD localization to stress granules upon stress. We demonstrate that many yeast PrLDs are sufficient for stress-induced assembly into...
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