Article

Computational investigation suggests that the cell adhesion sub-proteome is enriched for sites of pH-dependence and charge burial, whilst some key intracellular pathways may be shielded from pH fluctuations

2025-08-02

Abstract excerpt

Prediction of protein pH-dependence is generally made for individual proteins or pathways, and is also increasingly being used to aid protein functional design. Combining high-throughput pKa prediction methods with AlphaFold models allows pH-dependence to be studied across a proteome. Here, two methods and a variety of features for detecting pH-dependence and charge burial that is physiologically relevant, have be...

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Literature Corpus work: 65e03ad7-eed3-5da1-884f-d6e0fd7f03d4
DOI: 10.1101/2025.07.30.667722

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