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Article

Switching Protein Conformational Substates by Protonation and Mutation.

The journal of physical chemistry. B - 13 Dec 2018

Narayan Abhishek, Naganathan Athi N

Abstract excerpt

Protein modules that regulate the availability and conformational status of transcription factors determine the rapidity, duration, and magnitude of cellular response to changing conditions. One such system is the single-gene product Cnu, a four-helix bundle transcription co-repressor, which acts as a molecular thermosensor regulating the expression of virulence genes in enterobacteriaceae through modulation of...

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Identifiers

PMID: 30048131
DOI: 10.1021/acs.jpcb.8b05108
PMCID: PMC6314467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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