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Article

VAP-mediated membrane-tethering mechanisms implicate ER-PM contact function in pH homeostasis.

Cell reports - 27 Aug 2024

Hoh Kar Ling, Mu Baicong, See Tingyi, Ng Amanda Yunn Ee, Ng Annabel Qi En, Zhang Dan

Abstract excerpt

Vesicle-associated membrane protein (VAMP)-associated proteins (VAPs) are highly conserved endoplasmic reticulum (ER)-resident proteins that establish ER contacts with multiple membrane compartments in many eukaryotes. However, VAP-mediated membrane-tethering mechanisms remain ambiguous. Here, focusing on fission yeast ER-plasma membrane (PM) contact formation, using systematic interactome analyses and...

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Identifiers

PMID: 39110593
DOI: 10.1016/j.celrep.2024.114592

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