Article

Surface electrostatic networks control hydrophobic core remodeling in a pH-dependent switching protein

2026-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Communication between protein surfaces and their buried cores is central to protein structure and function, yet this phenomenon remains challenging to predict and control at high resolution. Changes in the protonation of surface ionizable residues communicate with the hydrophobic core, for example, in diverse pH-dependent protein functions. Hisactophilin, a histidine-rich actin- and membrane-bin...

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Literature Corpus work: a47135e4-50c3-52ea-8b62-d0828873bd4a
DOI: 10.64898/2026.07.16.738941

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