Article

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity

2020-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP + -dependent conversion of isocitrate to α-ketoglutarate (α-KG) to provide critical cytosolic substrates and drive NADPH-dependent reactions like lipid biosynthesis and glutathione regeneration. In biochemical studies, the forward reaction is studied at neutral pH, while the reverse reaction is typically characterized in more acidi...

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Literature Corpus work: 1470decb-b1d0-50fe-8958-012fd67f0d30
DOI: 10.1101/2020.04.19.049387

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