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Article

Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.

PloS one - 14 Mar 2011

Brett Christopher L, Kallay Laura, Hua Zhaolin, Green Richard, Chyou Anthony, Zhang Yongqiang, Graham Todd R, Donowitz Mark, Rao Rajini

Abstract excerpt

Protons, the smallest and most ubiquitous of ions, are central to physiological processes. Transmembrane proton gradients drive ATP synthesis, metabolite transport, receptor recycling and vesicle trafficking, while compartmental pH controls enzyme function. Despite this fundamental importance, the mechanisms underlying pH homeostasis are not entirely accounted for in any organelle or organism. We undertook a...

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PMID: 21423800
DOI: 10.1371/journal.pone.0017619
PMCID: PMC3056714

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NPC1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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