An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions.

doi:10.1016/j.devcel.2024.04.018

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions.

Developmental cell - 22 Jul 2024

Cereghetti Gea, Kissling Vera M, Koch Lisa M, Arm Alexandra, Schmidt Claudia C, Thüringer Yannik, Zamboni Nicola, Afanasyev Pavel, Linsenmeier Miriam, Eichmann Cédric, Kroschwald Sonja, Zhou Jiangtao, Cao Yiping, Pfizenmaier Dorota M, Wiegand Thomas, Cadalbert Riccardo, Gupta Govind, Boehringer Daniel, Knowles Tuomas P J, Mezzenga Raffaele, Arosio Paolo, Riek Roland, Peter Matthias

Abstract excerpt

Amyloids are known as irreversible aggregates associated with neurodegenerative diseases. However, recent evidence shows that a subset of amyloids can form reversibly and fulfill essential cellular functions. Yet, the molecular mechanisms regulating functional amyloids and distinguishing them from pathological aggregates remain unclear. Here, we investigate the conserved principles of amyloid reversibility by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Glycolysis

Share to Hydrogen-Ion Concentration

Share to Mutation

Share to Pyruvate Kinase

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 38788715
DOI: 10.1016/j.devcel.2024.04.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions.PMID 38788715Read ↗

Systematic identification of pH-sensing amyloid core motifs reveals a widespread mechanism for reversible protein assembly upon stressSemantic proximity Read ↗

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress.Semantic proximity Read ↗

Restoration of <i>PKM1</i> improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolismSemantic proximity Read ↗

Phosphorylation of Ser81 in human AGT reversibly inactivate enzyme function and mimics catalytic defects of certain PH1-causing mutationsSemantic proximity Read ↗

Glucose intake hampers PKA-regulated HSP90 chaperone activitySemantic proximity Read ↗

A superfolder variant of pH-sensitive pHluorin for in vivo pH measurements in the endoplasmic reticulum.Semantic proximity Read ↗

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.Semantic proximity Read ↗

Cancer and Alzheimer’s disease: intracellular pH scales the metabolic disordersSemantic proximity Read ↗

A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast.Semantic proximity Read ↗

Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.Semantic proximity Read ↗

Protonation- and substrate-regulated dimer opening couples brain-type creatine kinase to vesicular and actin-remodeling membranesSemantic proximity Read ↗

Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.