Article

VAP-mediated membrane tethering mechanisms implicate ER-PM contact function in pH homeostasis

2023-01-13

Abstract excerpt

VAMP-associated proteins (VAPs) are highly conserved endoplasmic reticulum (ER) resident proteins that establish ER contacts with multiple membrane compartments in many eukaryotes. However, VAP-mediated membrane tethering mechanisms remain ambiguous. Here, focusing on fission yeast ER-plasma membrane (PM) contact formation, using systematic interactome analyses and quantitative microscopy, we predict a non-VAP-pro...

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Literature Corpus work: 9823f22e-f61a-5ccf-9153-6ef528d21f92
DOI: 10.1101/2023.01.12.523872

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