Article

Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary Tauopathies

2026-07-13

Abstract excerpt

<title>Abstract</title> <p> Cerebrovascular alterations are widely observed in both Alzheimer’s Disease (AD) and primary tauopathies. Here, we hypothesized that mechanisms of cerebrovascular alterations are shared between AD and primary tauopathies. We performed single-nucleus RNA sequencing of <italic>postmortem</italic> human inferior temporal gyrus to characterize transcriptomic changes across cerebrovascul...

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Literature Corpus work: 0a3f1b34-31a0-5281-a212-6d72ee436180
DOI: 10.21203/rs.3.rs-10197270/v1

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